Isn't targeting inflammation just addressing a symptom? As long as the spike protein remains won't the inflammation continue? Or am I oversimplifying the entire pathophysiology...
Can I ask how melatonin helps? I take it regularly but very small doses as it tends to knock me about the next day. I take 1.5mg at night and sleep better than without. I find my symptoms are a little better the next day.
"The pathophysiology consists of any initiating event that causes an increase in acetylcholine release that will enhance depolarization at postjunctional membrane of muscle fibers. This causes a muscle contraction due to the increased release of calcium. As the same inciting event recurs, there is a continuous contracture of sarcomeres which forms a trigger point. It is also believed that the repetitive stimulation induces a sense of hypoxia within the muscle, which causes sensitization of nociceptors [4,5]. As evident by the traumatic nature of the disease, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been found to have intermediate and long-term effects on fatigue, respiratory function and carditis. The pain-related symptoms including myalgia and arthalgias account for 36% in a recent study [6]. Along with these symptoms, it also has been shown to cause lower limb weakness due to possible sclerosis or hypoxia [7,8]."
Part 5: References and Anecdotal Evidence
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What about hydroxyczne and acyclovir combo? Antihistamine and antiviral combo?
What type of dr would believe this?
https://www.jimmunol.org/content/early/2022/06/29/jimmunol.2200079
Isn't targeting inflammation just addressing a symptom? As long as the spike protein remains won't the inflammation continue? Or am I oversimplifying the entire pathophysiology...
Agreed, we should all be using at least a 3 prong approach:
Part 3: Laws of Probability
Sarah Myhill recommends amitripyline to deal organphosphates
Part 2: "Open Gate Theory"
Only half kidding here … why not just have a cigarette? Looking to nicotinic receptor agonists as treatment.
Have you thought it might be dopamine depletion which is inverse of acetylcholine? So low dopamine means high acetylcholine?
Exactly, just in my hypothesis (since acetylcholine is the modulator / regulator) =
So interesting, most fibromyalgia patients are deficient in both:
https://www.clinicalpainadvisor.com/chronic-pain/long-term-effects-of-covid-19-including-pain-syndromes/
https://www.researchsquare.com/article/rs-1999623/v1
https://portlandpress.com/biochemj/article/479/4/537/230829/A-central-role-for-amyloid-fibrin-microclots-in
Can I ask how melatonin helps? I take it regularly but very small doses as it tends to knock me about the next day. I take 1.5mg at night and sleep better than without. I find my symptoms are a little better the next day.
Update: Added SOME of the anecdotal feedback
Taking 1 potassium pill with each meal has helped me with what I believe to be tension headaches (I also was already taking magnesium).
99mg one
https://ibb.co/qWhNDdw
https://www.walshmedicalmedia.com/open-access/chlorpheniramine-maleate-nasal-spray-in-covid19-patients-case-series.pdf
https://ibb.co/fr2CtfQ
Interested to hear thoughts on Olopatadine (dual action) mast cell stabilizer
How important is the "chlorin ring" of Chlorphenamine ?
"The pathophysiology consists of any initiating event that causes an increase in acetylcholine release that will enhance depolarization at postjunctional membrane of muscle fibers. This causes a muscle contraction due to the increased release of calcium. As the same inciting event recurs, there is a continuous contracture of sarcomeres which forms a trigger point. It is also believed that the repetitive stimulation induces a sense of hypoxia within the muscle, which causes sensitization of nociceptors [4,5]. As evident by the traumatic nature of the disease, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been found to have intermediate and long-term effects on fatigue, respiratory function and carditis. The pain-related symptoms including myalgia and arthalgias account for 36% in a recent study [6]. Along with these symptoms, it also has been shown to cause lower limb weakness due to possible sclerosis or hypoxia [7,8]."
FaithlessnessLow9869
My theory was already confirmed by many, but now it's finally being confirmed in the main stream: